123I-MIBG SPECT for Evaluation of Patients with Heart Failure

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123I-MIBG SPECT for Evaluation of Patients with Heart Failure.

Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and r...

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Dynamic 123I-MIBG SPECT reflects sympathetic nervous integrity and predicts clinical outcome in patients with chronic heart failure.

123I-metaiodobenzylguanidine (123I-MIBG) is useful for assessment of the severity and prognosis of patients with chronic heart failure (CHF). To examine 123I-MIBG kinetics in the early phase soon after tracer injection, we performed dynamic single photon emission computed tomography (SPECT) in 76 patients with CHF and 17 control subjects. The consecutive 15 images of 2 min-dynamic SPECT were ac...

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Renal Function in Relation to Cardiac 123I-MIBG Scintigraphy in Patients with Chronic Heart Failure

The aim of this study was to explore if estimates of renal function could explain variability of (123)I-metaiodobenzylguanidine ((123)I-MIBG) assessed myocardial sympathetic activity. Furthermore estimates of renal function were compared to (123)I-MIBG as predictors of cardiac death in chronic heart failure (CHF). Semi-quantitative parameters of (123)I-MIBG myocardial uptake and washout were ca...

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Impaired lung 123I-MIBG uptake on SPECT in pulmonary emphysema.

UNLABELLED The aim of this study was to evaluate impaired lung uptake of (123)I-metaiodobenzylguanidine ((123)I-MIBG) on SPECT, compared with perfusion SPECT and morphologic CT, in patients with pulmonary emphysema (PE). METHODS (123)I-MIBG SPECT was performed at 15 min and 4 h after intravenous injection of (123)I-MIBG in 36 PE patients with a history of smoking and variable-extent low-atten...

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ژورنال

عنوان ژورنال: Journal of Nuclear Medicine

سال: 2015

ISSN: 0161-5505,2159-662X

DOI: 10.2967/jnumed.115.157503